IV Therapy in EdmontonEdmonton's Intravenous Therapy ExpertsNaturopathic Doctors specialized in IV Therapy
You can usually get an IV on your first visit
Call 780 757 8378 to book your IV consultNaturopathic Doctor Supervised✓ Over 15 years of IV Therapy experience
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Migraine |
IV ingredients that improve mitochondrial function are key |
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Lyme |
IV drips that serve to improve nerve restoration |
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IBD |
IV therapy bypasses a disrupted digestive tract in IBD |
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Heart Disease |
Infusions are available that restore the lining of blood vessels |
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Cognition |
Certain substances can improve energy production in the nervous system
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Interested in IV Therapy?
Call our Naturopaths!
(780) 757-8378
Advanced IV Therapy at TruMed Clinic in EdmontonAt TruMed Clinic, our experienced Naturopathic Doctors in Edmonton have spent over a decade refining advanced IV therapy protocols for a wide range of clinical concerns — from fatigue and inflammation to immune support, chronic disease, and longevity. We have administered thousands of IV treatments since 2010, combining traditional naturopathic principles with evidence-informed, integrative medicine. Each IV is customized, medically supervised, and designed to deliver bioavailable nutrients directly into the bloodstream for rapid, measurable results. Below are detailed case summaries and clinical insights illustrating how IV Therapy can profoundly impact patient outcomes in real-world settings. Myers’ Cocktail IV TherapyBackground: The Myers’ Cocktail is one of the most well-known IV therapies in naturopathic medicine, originating from the work of Dr. John Myers and later refined by Dr. Alan Gaby, who administered more than 15,000 treatments. The formulation includes B vitamins (B1, B2, B3, B5, B6, B12), Magnesium, Calcium, and Vitamin C — nutrients critical for cellular energy production and neuromuscular balance. At TruMed, we developed our own optimized version of the Myers’ formula with enhanced B12 (methylcobalamin) and additional riboflavin for more robust energy and neurological support. Clinical Application: Originally used for conditions such as asthma, migraines, fatigue, fibromyalgia, upper respiratory infections, and allergies, our clinic has found the Myers’ Cocktail especially effective for chronic fatigue and post-viral fatigue syndromes. Case Report: Protocol Summary: Vitamin C IV TherapyBackground: Intravenous Vitamin C allows for blood concentrations up to 100 times higher than what can be achieved through oral supplementation. These pharmacologic doses support immune defense, collagen synthesis, oxidative stress reduction, and — at very high levels — may exert selective cytotoxic effects against abnormal cells. At TruMed, our naturopaths distinguish between low-dose Vitamin C IV Therapy (up to 15g) for immune support and high-dose therapy (20–125g) for oxidative and metabolic applications, often combined with Hyperbaric Oxygen Therapy for synergistic results. Case Report: Protocol Summary: Glutathione IV TherapyBackground: Glutathione is the body’s master antioxidant — crucial for detoxification, immune modulation, and cellular protection. It neutralizes reactive oxygen species, aids in heavy metal clearance, and supports liver, neurological, and skin health. Clinical Uses: Our naturopathic doctors use IV Glutathione in conditions such as Lyme disease, multiple sclerosis, inflammatory bowel disease, mold toxicity, and anti-aging medicine. It’s also sought after for skin brightening due to its influence on melanin synthesis. Case Report: Protocol Summary: NAD+ IV TherapyBackground: Nicotinamide Adenine Dinucleotide (NAD+) is an essential coenzyme in cellular respiration and energy metabolism. It supports mitochondrial function, DNA repair, and longevity pathways through Sirtuin activation. Oral NAD+ precursors (NMN, NR) provide limited systemic bioavailability, whereas intravenous delivery produces a profound and immediate increase in cellular energy output. Case Report: Protocol Summary: Alpha Lipoic Acid (ALA) IV TherapyBackground: Alpha Lipoic Acid is both a potent antioxidant and mitochondrial cofactor that regenerates other antioxidants and enhances glucose metabolism. Orally, it is poorly absorbed (~30%), making IV delivery the preferred clinical method. Case Report: Protocol Summary: Plaquex (Phosphatidylcholine) IV TherapyBackground: Plaquex delivers phosphatidylcholine, the main phospholipid in cell membranes. By replenishing damaged membranes, it supports vascular, hepatic, and neurological health. Our naturopaths use Plaquex IV Therapy in cardiovascular disease, liver dysfunction, Lyme disease, neurodegenerative conditions, and toxin exposure. Case Report: Protocol Summary: Curcumin IV TherapyBackground: Curcumin, the active compound in turmeric, has strong anti-inflammatory, antioxidant, and anticancer properties but poor oral bioavailability — making it a strong candidate for intravenous administration. Case Report: Protocol Summary: NADH IV TherapyBackground: NADH, the reduced form of NAD+, donates electrons to the mitochondrial respiratory chain, enhancing ATP production. It has shown benefit in chronic fatigue syndrome, fibromyalgia, and Parkinson’s disease when administered intravenously. Case Report: Protocol Summary: Why Patients in Edmonton Choose TruMed for IV TherapyTruMed Clinic is a leader in IV therapy and naturopathic medicine in Edmonton, offering some of Canada’s most comprehensive nutrient infusion protocols. All treatments are designed and monitored by licensed Naturopathic Doctors with extensive experience in advanced intravenous nutrition, detoxification, and metabolic therapies. Whether you’re seeking more energy, enhanced recovery, improved immunity, or integrative cancer support, TruMed’s customized IV Therapy programs provide evidence-based, professional care in a comfortable clinical setting. Experience the difference of science-driven naturopathic IV Therapy in Edmonton — where every treatment is tailored, every result is measured, and every drip moves you closer to optimal health. Iron Infusions in EdmontonExperts in IV therapy in Edmonton since 2010
See our iron page The top IV therapy treatments in Edmonton are: IV NAD, IV Glutathione and various vitamin drips, injections and infusions such as the Myers Cocktail.NAD+ IV Therapy in EdmontonOur Naturopaths give a wide range of doses of NAD+ IV therapy Treatments. NAD+ injections are most often dosed150-400mg at our Edmonton office. Most commonly we use NAD injections to improve energy in our Edmonton patients. Because if it's strong relationship to mitochondrial function we use NAD infusions in fibromyalgia, and chronic fatigue syndrome. Our office has basically pioneered NAD IV Therapy in Edmonton as we have been doing it since 2018 and have administered literally thousands of NAD injections It is common to experience side effects related to the rate of administration with regards to intravenous NAD - it cause nausea, headaches, lightheadedness and chest pressure. We tend to run NAD fairly slowly especially if it's your first time getting an NAD injection at our office. NAD+ IV Therapy in EdmontonThe Mitochondrial MVPEver feel like your battery’s stuck at 20%? That’s where NAD+ injections and IV therapy come in. Why NAD+ IV Therapy WorksOral NAD+? Mostly broken down in your gut. More mental clarity Our Edmonton NAD+ IV Options:
We’ve delivered thousands of NAD+ injections in Edmonton since 2018. Side effects are rare and typically only occur when the infusion is rushed (which we don’t do). NAD+ works beautifully with Hyperbaric Oxygen Therapy, amplifying oxidative phosphorylation for elite-level recovery and repair. Glutathione infusions in EdmontonOur naturopaths have extensive experience with Glutathione IV Therapy.
We have worked with high dose Glutathione IV treatments since 2010- our naturopaths have given thousands of Glutathione injections at our Edmonton office. Even with high doses, glutathione IVs are extremely well tolerated. Intravenous Glutathione infusions are often combined with intravenous vitamin C and is administered administered fairly rapidly in drip or IV push format and is typically added to the end of other IV treatments. For skin health we often use 1-2 weekly Glutathione injections. For neurological health, such as Parkinson's, ALS, MS - we may suggest Glutathione injections daily initially with a nutrient bag prior to the glutathione to enhance its action. Most commonly we are using glutathione injections for the following: Inflammation, multiple sclerosis, Skin Brightening, skin Lightening, Detoxification and Parkinson's and Lyme disease.Glutathione has been colloquially named "gluta" by some of our patients. As discussed, Glutathione is extremely well tolerated when given intravenously in our experience it has an almost non-existent incidence of side effects. ✨ Glutathione IV Therapy & Injections in EdmontonThe Skin-Brightening Antioxidant QueenReady to glow? Glutathione IVs and Injections at TruMed are your not-so-secret weapon for glowing skin, cellular detox, and antioxidant defense. This tripeptide is your body’s master antioxidant—fighting oxidative stress, supporting liver detox, and inhibiting melanin production to lighten and even out your skin tone. We combine Glutathione IV therapy with high-dose Vitamin C for maximum results, and tailor dosing based on your goals: skin health, neurological support, or deep detox. Brighten & even out skin tone Glutathione IV Therapy in Edmonton since 2010. We typically recommend 1–2 sessions per week for 4–6 weeks for skin goals. Bonus: topical options (like niacinamide) and oral glutathione boosters can enhance your results. Vitamin Drips, Injections and Infusions in Edmonton.
We've given thousands of Vitamin IV Drips to our Edmonton patients. We offer our Myers Cocktail in a small volume IV Vitamin Drip format and most frequent uses are energy, mood, cognition, athletic recovery and infections. Our Naturopaths typically suggest IV drips once weekly for about a month. Effects of IV drips are quick!! Most patients feel a boost by the next day. Most commonly we use IV Drips for Fatigue, Migraine, Fibromyalgia, Depression, and Low Mood. Our Naturopaths have administered literally thousands of Vitamin Drip IVs at our Edmonton office with a very low incidence of side effects. Questions about IV drips?? Get in touch!! IV Therapy & Injections in Edmonton — Powered by Science, Guided by NaturopathsFeel Better. Think Sharper. Glow Brighter. Right Here at TruMed.Looking for IV therapy, injections, or vitamin drips in Edmonton that actually do something? Whether it’s NAD+ IVs for energy and brainpower, Glutathione Injections for radiant skin and detox, or Vitamin IV Drips for mood, recovery, or immune support—we’ve got you covered. Vitamin Drips & Injections: Edmonton’s Favorite Pick-Me-Up The Myers Cocktail & BeyondNeed an energy boost? Immune support? Faster recovery from workouts or burnout? Enter: Vitamin IV Drips at TruMed. Our most popular formula? The Myers Cocktail—a powerful blend of B-vitamins, Vitamin C, magnesium and calcium designed to fuel energy metabolism and nervous system balance. Common reasons patients choose a Vitamin IV Drip in Edmonton:
Most patients feel a lift within 24 hours. We often suggest a weekly Myers IV for 3–4 weeks to build momentum, then monthly for maintenance. Treatment time? Just 10–15 minutes. Need extra antioxidant power? We can add Glutathione to your IV drip at the end—an easy upgrade for detox and skin health. Injections for Quick SupportDon’t have time for a full IV drip? Our vitamin and nutrient injections are perfect for busy schedules:
Fast, effective, and ideal between IV sessions. Science + Experience = TruMedAt TruMed Naturopath Clinic in Edmonton, we’ve been leaders in IV therapy, nutrient injections, and naturopathic care since 2010. With thousands of infusions under our belt, you’re in expert hands. Our Naturopathic Doctors combine clinical lab testing with advanced natural therapies to help patients with:
We don’t just treat symptoms—we dig deep and personalize your care. Ready to Feel Amazing?Call us at (780) 757-8378 to book your IV Therapy consultation in Edmonton. Recharge your energy. Visit TruMed Naturopath Clinic in Edmonton — Where cutting-edge meets natural healing.
Why give Vitamin C Intravenously?Oral dosing of Vitamin C achieves a maximum serum concentration of less than 0.25 mM due to the limited absorptive capacity of the gastrointestinal tract. Whereas, intravenously administered vitamin C will increase serum levels more than 100-fold: up to 30 mM (Levine 2011). How can IV Vitamin C help in Cancer?When present at such high serum concentrations, vitamin C generates cytotoxic reactive oxygen species, such as hydrogen peroxide. In normal cells, hydrogen peroxide is metabolized to water and oxygen by the enzyme catalase. However, tumor cells lack catalase, leaving them vulnerable to the cytotoxic effects of hydrogen peroxide (Chen 2005). Tumor cells selectively take up more vitamin C compared to normal cells through an upregulated metabolic need for glucose due to similarities between Vitamin C and Glucose (Agus 1997). Can IV Vitamin C be used alongside chemotherapy?In many cases yes. For instance, 2014 pilot trial looked at stage III-IV ovarian cancer patients receiving IV Vitamin C therapy alongside chemotherapy. Women who received IV Vitamin C treatment reported fewer side effects related to chemotherapy in almost all categories of toxicity and median time to disease progression or relapse was 8.75 months longer in the Intravenous Vitamin C group - 25.5 vs 16.75 months (Ma 2014). Another study looked at data from 125 breast cancer patients (stages IIa to IIIb) treated with a modest 7.5g IV Vitamin C in addition to standard therapy for at least 4 weeks. IV Vitamin C administration resulted in a significant reduction of complaints induced by the disease and chemo-/radiotherapy (Vollbracht 2011). Because of data like this our Naturopathic Doctors frequently suggest simultaneous intravenous Vitamin C treatment alongside many common chemotherapy regimens. IV Therapy with Vitamin C is frequently given once weekly on chemotherapy "off-days." IV Vitamin C and Quality of Life:A review of all patients receiving IV Vitamin C for cancer at the Thomas Jefferson University Hospital over a 7 year period looked at 86 patients who received a total of 3034 doses of IV Vitamin C (50 to 150g). 32 patients received only IV Vitamin C as part of their cancer care (1197 doses) and 54 patients received ascorbic acid in conjunction with chemotherapy (1837 doses - which included drugs such as paclitaxel, carboplatin, sorafenib, irinotecan, and gemcitabine). Bladder, Breast, Colon, Endometrial, CLL, Liver Cancer, Lung, Lymphoma, Mesothelioma, Ovarian, Pancreatic, and Prostate Cancer were the main cancers in this review. All patients receiving IV Vitamin C, had a significant improvement or stability in fatigue, bowel habits, and pain symptoms (Bazzan 2018) 60 patients with newly diagnosed cancer who visited participating institutions in Japan were used for another study. In most of the study patients (95.0%), the primary lesions were solid tumors (Lung, Breast, Stomach, Colon, Uterus, Liver, Prostate, Ovary, Pancreas) and 61.7% had advanced cancer with metastatic lesions and 34 patients had co-administered standard care (mostly chemo). The global health status scores showed significant improvement from after 4 weeks of IV Vitamin C therapy as well as significant improvement in physical, emotional, cognitive, and social functioning with fatigue showing the largest improvement (Takahashi 2012). Vitamin C and Infections:Vitamin C is needed for neutrophil function and can stimulate the production of interferon and other anti-viral cytokines, as well as direct antiviral properties such as hindering viral infection, replication and protein assembly. Observations from the literature that millimolar levels of Vitamin C (pharmacologic concentrations as provided by IV Therapy) hinder viral infection and replication in vitro such as Herpes simplex viruses, cytomegalovirus, and parainfluenza, influenza and picornaviridea viruses to infect cells. With this in mind, data looking at 178 patients with elevated Epstein Barr Virus antibodies that were treated with intravenous vitamin C (7.5 g to 50 g infusions) was analyzed. Most of these patients had a diagnosis of chronic fatigue syndrome. Their data showed a reduction in antibody levels over time during IV Vitamin C therapy. The authors concluded "our data provide evidence that high dose intravenous vitamin C therapy has a positive effect on disease duration and reduction of viral antibody levels." (Mikirova 2014). 5 benefits of IV Vitamin C#1 - DosageIntravenous use of Vitamin C allows our Naturopaths to dose Vitamin C in dramatically higher amounts than what is possible with oral administration. Most adults can tolerate a maximum of 5-6 grams in a single dose when Vitamin C is taken orally, however, with IV Therapy we can dose 20 fold higher amounts of IV Vitamin C - anywhere from 2 grams up to 125 grams! #2 - Pharmacologic EffectsIV Vitamin C Treatments behave differently in the body than oral Vitamin C. For instance, oral dosing of Vitamin C functions principally to enhance anti-oxidant and immune related functions of Vitamin C. However, intravenously Vitamin C has direct anti-viral and oxidative effects hence its use in infections as well as Cancer. #3 - CompatibilityIV Vitamin C drips are water soluble and can easily be combined with other water soluble IV Therapy ingredients. Frequently our Naturopaths add additional B Vitamins and Minerals (such as Magnesium, Selenium, Calcium and Zinc) into our Vitamin C IV treatments. #4 - SafetyIntravenous Vitamin C is remarkably safe and the same can be said for nutritional IV Therapy in general. Our Naturopaths have literally given thousands of IV Therapy treatments at our Edmonton office. IV Vitamin C drips are remarkably well tolerated even at high doses, and in sensitive populations like the elderly. #5 - EfficacyVitamin C IV Therapy frequently gets the job done and done well. Whether it comes to acute infections, chronic infections, boosting immunity or alternative cancer support Vitamin C infusions have a very broad use and can be effective in a large range of conditions. What's in a Myers Cocktail?The original John Myers Cocktail was administered in a 10-ml syringe by slow IV push. It was a combination of B1, B6, B Complex, Calcium, Magnesium, Vitamin C and dilute hydrochloric acid. The Alan Gaby Myers Cocktail was administered manually in a still fairly small 20ml syringe. It was most commonly 1 ml each of B6, B5, B complex, B12, 4 ml of magnesium, 2 ml of calcium, 6 ml of Vitamin C, and 8 ml of sterile water The TruMed Myers Cocktail is much stronger in many ways. The IV that Dr. Muradov primarily uses is a small volume IV (base fluid of 30-100ml) that has an additional 50% of most of the B Vitamins as recommended by Dr. Gaby as well as added Riboflavin and up to 7.5x the dose of B12 all in a small volume IV bag treatment. We approximate the hypertonicity of the Gaby Myers in our IV treatment. What is the Myers Cocktail IV used for?Originally the Myers was suggested for use (as per case reports from Dr. Gaby): Fatigue, Migraine, Asthma, Fibromyalgia, Depression, Upper Respiratory Tract Infections, Seasonal Allergy, Narcotic Withdrawal, Chronic Hives, Athletic Performance, Hyperthyroidism and COPD. In particular, we frequently use the TruMed Myers in Fatigue, Anxiety and Depression and Athletic performance on an extremely regular basis. We love using the Myers at our office to increase brain levels of nutrients for mood and brain fog. It seems that certain patients presumably have a higher-than-normal requirement for particular nutrients like Vitamin B12. The large blood spikes of nutrients from Intravenous administration is able to drive more nutrients into the brain. How much does a Myers IV treatment cost?At TruMed our Naturopaths use a stronger, drip format Myers which is usually about $175 per treatment. How many Myers IV treatments do I need to feel better?Frequently, patients that respond to the Myers will respond within 24 hours of their first injection. Occasionally, it can take 3-4 consecutive weekly treatments for a full response. Myers Cocktail ResearchDr. Alan Gaby's monograph on the Myers is still the "bible" on the therapy - discussing numerous case reports. A 2007 pilot trial giving a modified Myers IV for treatment resistant Fibromyalgia found pain levels steadily decreased with energy steadily increasing with each IV treatment over 8 weeks. A 2009 study found improved tender points, pain, depression, and quality of life from the Myers over 8 weeks in Fibromyalgia patients. Our clinic in Edmonton has verified the results of the above research in our own patient pool. Our Myers: B1, B2, B3, B5, B6, B12 & Magnesium
B1: Thiamine is needed just prior to the Krebs Cycle (Thiamine Pyrophosphate and Pyruvate Dehydrogenase Enzyme makes acetyl-CoA from pyruvate). Orally and Intravenously administered Thiamine ("parenteral Thiamine") has been successfully in MS Fatigue. Through similar mechanisms we rely on Intravenous Thiamine at our office as an important component of IV treatments for fatigue. One practitioner reported that intravenous administration of intravenous vitamins could “dispose of delirium tremens in a matter of hours." It appears that intravenous infusions of vitamin C, B1 and B3 are the most important Vitamins to be used. B2: In the body there are two active coenzyme forms of B2 (Riboflavin): FMN (flavin mononucleotide - also called riboflavin 5’-phosphate) and FAD (flavin adenine dinucleotide) In a 1996 study, a maximum of 27mg of Riboflavin was able to be absorbed orally in contrast to intravenous Riboflavin injections. At our Edmonton office we can easily administer 50-100mg of FMN (Riboflavin-5'-phosphate). Riboflavin is best known for its use in migraine prophylaxis where doses are often 400mg daily orally. Interestingly, Intravenous Thiamine may have a role in migraine treatment as well. FADH generated in the Krebs Cycle is an electron donor in the electron transport chain for ATP generation so it's an important part of our IV treatments for fatigue as well as for athletic performance. Not surprisingly, Riboflavin requirements increase with exercise. B3: There are two main forms of B3 niacin or nicotinic acid and niacinamide or nicotinamide (niacinamide is the form we use in IV Therapy primarily) and all of these are precursors to NAD+. A deeper discussion into the mechanisms of Intravenous NAD+ will be in the NAD+ section. Our office uses Niacinamide exclusively in IV Therapy format as it is well tolerated in high doses and does not cause flushing as seen with Niacin. Data exists for the use of intravenous and orally administered Niacin (nicotinic acid) in the acute treatment of both tension type and migraines. Discussed below there is data for intravenous magnesium in the acute treatment of headaches which we've seen more clinically effective at our Edmonton office. Niacin is known to affect blood lipid levels and a study looking at intravenous niacin gave a possible explanation: that is suppresses endogenous lipoprotein hydrolysis. Niacinamide by inhibiting tryptophan pyrrolase (an enzyme) and can increase the amount of tryptophan available to be converted to serotonin and therefore improve mood. B5: Pantothenic acid is a component of coenzyme A (CoA) which is then added to Pyruvate to produce Acetyl-CoA which enters the Krebs cycle, so B5 is intimately involved in cellular energy production. So B5 is always added to our IV Therapy treatments for fatigue. In fact, disordered pantothenic acid and CoA synthesis has been implicated in both Chronic Fatigue Syndrome as well as Fibromyalgia, which is another reason our Naturopathic Doctors always have clinically relevant quantities of Dexpanthenol in our IV Therapy treatments for these conditions. Injections of Dexpanthenol (the form used exclusively intravenously) at 500 mg intramuscularly daily for 5 days decreases the time to a bowel movement in patients with chronic or occasional constipation. Also, Pantothenic acid is needed for Adrenal hormone synthesis and is therefore helpful for energy production in that regard as well. "Pantothenic acid supplementation stimulates the ability of adrenal cells in male rats to secrete corticosterone." With this in mind, B5 added to intravenous treatments is a must in the context of IV Therapy for adrenal fatigue. B6: Pyridoxine exists in three forms: pyridoxine, pyridoxal, and pyridoxamine. Pyridoxal's phosphate ester (pyridoxal 5’-phosphate or P5P) is a coenzyme and is the main active form of vitamin B6. Some data exists that suggests that deficiency of Vitamin B6 is involved in neurological sequelae of SARS Cov-2. Intravenous Vitamin B6 has been used in seizure management. Injections of Vitamin B6 into the acupuncture point PC6 can be helpful for nausea and vomiting of pregnancy. Also, injections of Vitamin B6 improves immune response in the critically ill and can improve hair loss in diffuse female alopecia. At our Edmonton office our Naturopaths primarily use Pyridoxine Hydrochloride in most of our IV Therapy treatments. However, we do also have pyridoxal 5’-phosphate (P5P) if we want a more robust response especially in mood concerns in addition to other ingredients such as methyl-B12, methyl-folate and Magnesium sulfate.
Our office frequently considers the use of Methyl-B12 in peripheral nerve injury - conditions such as diabetic neuropathy, and sciatica as well as herpetic neuralgia. Depression is a reversible manifestations of vitamin B12 deficiency and we've seen numerous chronically depressed or anxious patients who had substantial clinical improvement in mood after receiving intramuscular injections or infusions containing predominantly B12. Of course, B12 infusions are well known to improve fatigue (likely through increased succinyl-CoA). Magnesium: Magnesium is involved in over 300 different enzymatic reactions in the body. Similar to Vitamin C, oral consumption of magnesium results in only a small increase in blood Magnesium levels, whereas Magnesium infusions can triple the serum levels. With regards to energy production, ATP must bind to a magnesium ion to be biologically active. In our experience, Magnesium infusions can be extremely helpful in fatigue and chronic fatigue type syndromes.
Glutathione ResearchIn one study, serum levels of bilirubin, ALP and GGT (all common measures of liver functions) were measured in 42 Lyme patients.
Measurements before and after long-term treatment with intravenous ceftriaxone with co-administration of oral or intravenous α-lipoic acid (600 mg daily) and Glutathione (100 mg orally or up to 2.4 g intravenously daily) over an average of 75 days of treatment.
None of the patients developed biliary colic and there were no significant changes in serum bilirubin, alkaline phosphatase or GGT levels.
In fact this study is meant to indicate that not only does intravenous Glutathione not affect liver enzymes adversely but it can prevent liver function abnormalities from other treatments.
Similarly, at our Edmonton office our Naturopathic Doctors have not observed Glutathione adversely affect liver enzymes with repetitive treatment (2-3x weekly typically) over periods of 2-3 months.
In the landmark study of intravenous Glutathione and its use in Parkinson's, 600mg of Glutathione was given intravenously twice daily for 30 days in nine patients with early, untreated Parkinson's disease.
The IV Glutathione therapy had no adverse effect on blood chemistries, liver function tests, blood counts.
Although the total daily Glutathione was 1200mg, this study in our opinion demonstrates that repetitive, daily moderate dose once again does not affect liver function tests adversely.
Aside from the safety, all patients improved significantly after Glutathione infusions, with a 42% decline in disability.
Once IV Glutathione was stopped the therapeutic effect lasted for 2-4 months.
In one Italian study, looking at chronic fatty liver disease (of various origins) intravenous administration of high dose Glutathione.
Glutathione infusions significantly improves liver function tests such as bilirubin, AST, ALT, GGT "even several months after treatment interruption."
Lastly, in a 2019 animal model study - high dose intravenous Glutathione was used specifically for the purpose of skin whitening.
Glutathione drips were given to the animals three times weekly for 3 weeks and no differences were seen in liver or renal parameters such as AST, ALT, creatinine, BUN, as well as CBC counts.
In summary, Glutathione is extremely well tolerated when given IV either high doses or repetitively.
NAD BackgroundNAD+ is synthesized via three pathways: de novo biosynthesis, the Preiss-Handler pathway, and the salvage pathway. The Preiss-Handler pathway synthesizes NAD+ from nicotinic acid (Niacin) The salvage pathway recycles nicotinamide/niacinamide to nicotinamide mononucleotide (NMN) by NAMPT and NMN is converted into NAD+, and in this pathway nicotinamide riboside (NR) converts into NMN. It's been suggested that NAD+ cannot enter cells from the blood directly, however, our clinical experience with NAD+ IV Therapy - where patients can feel beneficial effects instantly, seems to dispute this claim. Apparently NMN and NR are thought to enter cells directly however our Naturopathic doctors have not seen much clinical effect using these orally in our Edmonton patients, whereas the effect from IV Therapy is obvious and frequently profound. NAD+ plays an essential role in energy production as it's involved in glycolysis and the citric acid cycle (Krebs Cycle) forming NADH during these processes which we also work with Intravenously at our Edmonton office. The Sirtuins are 7 different NAD+-dependent deactylase enzymes that regulate different cellular pathways. Poly ADP-ribose polymerases (PARPs) are NAD+ dependent enzymes and are involved in DNA repair. An age-dependent increase the glycoprotein CD38, may contribute to cellular NAD+ depletion and impaired mitochondrial function. NAD ResearchO’ Hollaren (1961) - The first published data on NAD+ in addictive disorders. O’ Hollaren (1961) - IV NAD+ for the treatment of over 104 cases of addiction to substances including alcohol as well as heroin, opium, morphine, codeine, cocaine, amphetamines, barbiturates and tranquilizers. Susan Broom (2019) - "Intravenous Administration of Nicotinamide Adenine Dinucleotide [NAD+] Significantly Reduces Self Report Craving Ratings Associated with Opiate and Alcohol Withdrawal - a pilot study looking at IV NAD+ in 60 patients." Grant (2019) - Demonstrated the fate of IV NAD+ namely that there is rapid uptake of NAD+ when given intravenously. Rutherford (2020) - A case report demonstrating significant reduction of tremor in a Parkinson's patient after receiving a BR NAD+ protocol. Blum (2022) - IV NAD with multi-vitamins, glutathione, alpha lipoic acid and amino acids with regards to cravings
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