TruMed - Intravenous Treatment in Edmonton

Other Treatments our Naturopaths work with:

Curcumin

Alpha Lipoic Acid

PolyMVA

NADH

B12

Curcumin in Edmonton

Our Naturopaths work with Curcumin Treatment

IV Curcumin Treatment Edmonton Curcumin

Curcumin "diferuloylmethane" is a yellow pigmented active ingredient from Turmeric (Curcuma longa)

Curcumin Facts

Curcumin basics:

Curcumin has numerous effects on cancer cell including inhibition of NF-κB, and affects common cancer pathways utilizing STAT3, mTOR and transforming growth factor (TGF)-β as well as affecting apoptosis.

Curcumin is notoriously poorly absorbed and various efforts have gone into attempting to increase the availability of Curcumin.

Our Naturopaths typically ramp the dose and usually give doses between 300 to 500 mg of per session.

Curcumin is well tolerated when diluted appropriately.

Curcumin treatment can be given back to back with Quercetin for synergistic effects in Cancer and inflammation.

Curcumin and Cancer

Preliminary data: Cell line evidence exists in breast, prostate, lung, bladder, cervical and gastric cancer (in combination with quercetin in particular which we can also give intravenously), melanoma, multiple myeloma, glioblastoma, and chronic myelogenous leukemia.

Colon Cancer - Oral curcumin in advanced colorectal cancer patients refractory to standard chemotherapies resulted in stable disease for 2-4 months in five of fifteen patients.

Pancreatic Cancer - As a standalone treatment, high dose Curcumin caused ongoing stable disease for one patient and tumor regression in another in a 2008 trial. In combination with Gemcitabine it increased median survival time in a 2011 and 2010 study.

Breast Cancer - Patients with breast cancer were given Curcumin with Docetaxel and results suggested an enhanced synergistic effect.

Prostate Cancer - In a 2019 trial, patients who finished the period of androgen deprivation were given curcumin or placebo group and the proportion of patients with PSA progression was significantly lower in the Curcumin group.

Curcumin Phase I Study using liposomal curcumin showed marked reductions in tumor markers in one colorectal cancer patient as well as a prostate cancer patient.

Doses given were 200-500mg which is similar to the strength we use at our Edmonton office for a single treatment.

Beyond Cancer

Pain: Curcumin can improve symptoms of Osteoarthritis.

Cardiovascular Disease: Oral curcuminoids can reduce triglycerides, increase HDL and reduce LDL.

Mood: Oral curcumin can improves symptoms of depression when taken along with an antidepressant.

Autoimmunity: Data exists demonstrating beneficial effects of Curcumin in Ulcerative Colitis, Crohn's & Psoriasis.

Bottom line: Curcumin is notoriously poorly absorbed when taken by mouth

Our Naturopathic Doctors use Curcumin in Cancer, Pain and Autoimmunity

ALA

Anti-oxidant, Anti-inflammatory & Glutathione BoostingAlpha Lipoic Acid in Edmonton

ALA Facts

Alpha-lipoic acid (thioctic acid) Lipoic Acid is an endogenously produced anti-oxidant.

Alpha Lipoic Acid Basics:

ALA promotes the regeneration of other antioxidants such as vitamin E, vitamin C, and glutathione. Therefore when given Intravenously, it can be stacked with Glutathione and Vitamin C for an enhanced effect.

ALA is a coenzyme with Thiamine Pyrophosphate (B1) on Pyruvate Dehydrogenase, in the conversion of pyruvate into acetyl-CoA - for entry into the Krebs Cycle so it's intimately involved in the energy production process with B1 & B5.

Lipoic Acid is only about 30% absorbed from dietary or supplemental sources, and food reduces the absorption of it as well by about 30% making it an excellent candidate for enhanced levels with intravenous therapy administration.

When consumed, ALA is reduced to DHLA and when taken, almost twice as much R(+)alpha-lipoic acid is absorbed as the S(-) form so our Naturopaths have a preference for using R+ Lipoic Acid.

ALA is a cofactor for certain mitochondrial enzymes and has antioxidant activity and anti-inflammatory activity - TNFα, IL-6 and IL-1 are suppressed via NF-κB inhibition therefore we strongly consider its use in neuronal inflammatory conditions like Lyme and MS.

Lipoic acid can scavenge free radicals both intra- and extracellularly, and is both water and fat soluble, and easily crosses the blood brain barrier, so it's ridiculously versatile in its action, hence its use in neurological concerns.

Furthermore, ALA increases neuronal blood flow, improves neuronal glucose uptake, increases amounts of reduced glutathione in neurons, and improves neuronal conduction velocity.

Lipoic Acid increases the bile excretion of organic mercury by forming a stable complex.

Lipoic Acid and Cancer:

Some exciting data exists regarding use of Lipoic Acid in the "metabolic" treatment of Cancer.

Our Naturopaths have seen some really unique results at our Edmonton office over the years when Lipoic Acid is used as part of a comprehensive cancer treatment protocol.

Therapy with Alpha Lipoic Acid is generally well tolerated but it needs to be given at least over a 20-30 minute period and it's recommended that patients do not have it administered on an empty stomach as it can cause nausea and headaches (presumably because of a blood sugar lowering effect).

In conjunction with LDN, Lipoic Acid has some profound case reports in Pancreatic, and Renal Cancer. Whereas, its use with Garcinia and LDN has been shown in Lung, Esophageal, Uterine and Brain Cancers.

Next generation Lipoic Acid: PolyMVA

Lipoic Acid Mineral Complex contains Molybdenum, Rhodium, Ruthenium, Palladium, B1, B2, B12, N-Acetyl Cysteine & Formyl Methionine.

Lipoic Acid is "irreversibly bound" to Palladium and B1 and is said to be a much more potent agent with regards to the creation of Acetyl-Coa from Pyruvate for the Krebs Cycle.

Furthermore, PolyMVA can dramatically "rev up" numerous Krebs Cycle and Electron transport chain enzymes for enhanced energy production (ATP).

PolyMVA has been studied in Multiple Sclerosis-Associated fatigue with 80% of subjects demonstrating statistically significant improvements on three MS fatigue scales as well as Lyme-associated fatigue.

Our Naturopathic doctors have been using PolyMVA at our Edmonton office since 2017 for metabolic cancer support as well as for MS, Lyme and Chronic fatigue.

We've been recently using it in neurodegenerative diseases such as ALS and Parkinson's.

Two main drawbacks of PolyMVA - it requires a long time for administration and it extremely costly especially for use in Cancer. Doses for Fatigue are much lower and are somewhat more cost effective.

Bottom line: Our Naturopaths use Lipoic Acid primarily in the metabolic treatment of Cancer and in neurological inflammatory issues like MS & Lyme.

PolyMVA is also used for Cancer therapy and for improving mitochondrial function in various diseases with a chronic fatigue component.

B12 Treatment

A master for energy, mood, focus and memory.

B12 in Edmonton

B12 Facts

Vitamin B12 has two active forms, methylcobalamin and adenosylcobalamin "cobamamide"

B12 Biochemistry:

Adenosylcobalamin is the major form in cells that's stored in the mitochondria whereas Methylcobalamin is found in the cytosol of the cell and it predominates in blood.

Insanely, humans require B₁₂ for just two enzymes: methylmalonyl-CoA mutase & methionine synthase.

Adenosylcobalamin is a cofactor for the enzyme methylmalonyl-CoA mutase that catalyzes the conversion of methylmalonyl-CoA to succinyl-CoA, which is a key component of the Krebs Cycle for energy production.

So it's quite possible that administration of the Adenosyl form of B12 may in fact be superior to other forms for fatigue.

Our Naturopaths measure methylmalonic acid as part of our DUTCH hormone test - so, if your Adenosylcobalamin is low, then the methylmalonyl-CoA builds up and we can measure it in the urine. THIS IS IN THE MITOCHONDRIA.

Methylcobalamin methylates homocysteine to methionine (via methionine synthase). The cobalamin is then remethylated from methyltetrahydrofolate, which results in the formation of tetrahydrofolate. This is in the CYTOPLASM.

In the blood, Transcobalamin-B12 complex is taken up into cells by receptor-mediated endocytosis after binding to the transcobalamin receptor.

Then methyl and adenosyl are cleaved back into a cobalamin, by binding to the CblC protein which requires Glutathione to work.

If the cobalamin reacts with water it forms Hydroxocobalamin.

Reductive methylation of cobalamin to methylcobalamin is done using methionine synthase reductase in which SAMe acts as a methyl donor

Once cobalamin enters the mitochondria, it's adenosylated to make adenosylcobalamin.

B12 Uses:

B12 is a mainstay at our Edmonton office for fatigue, especially if there are simultaneous neuropsychiatric concerns like anxiety or depression.

B12 is a marvelous treatment that works extremely rapidly.

The RDA for B₁₂ is around 2.5 μg/day, which is also the amount that saturates intrinsic factor, and then there is some passive diffusion of B12 which happens in the digestive tract as well. This RDA, is the lowest of all the vitamins but with that said, it is probably the one that benefits the most from doses that dramatically exceed this, especially when given via different routes.

Our Naturopaths use B12 for improving a wide variety of health areas including:

Cardiovascular

Hyperhomocysteinemia

Dermatological

Herpes zoster

Urticaria

Ear, nose, and throat

Hearing loss

Olfactory dysfunction (if deficient)

Taste disorders (if deficient)

Tinnitus

Musculoskeletal

Low Back pain

Bursitis

Heel Spurs

Neurological

Migraine

Neuritis

Peripheral neuropathy

Sciatica

Trigeminal neuralgia

Autism

Psychiatric

Alzheimer’s disease

Anxiety

Dementia/cognitive decline

Depression

Postpartum depression

Other

Age-related macular degeneration

Alcohol addiction

Anesthesia side effects

Aphthous ulcers

Asthma

Chronic fatigue syndrome

Diabetes

Fatigue

B12 Dosing:

Our Naturopathic Doctors are usually dosing between 1.5mg to 15mg depending on the concerns and frequently use Methylcobalamin, but have used Hydroxocobalamin and are gaining experience with Adenosylcobalamin.

The B12 dose will be individualized by your Naturopath depending on your specific concern.

For most health conditions, it's given 1x weekly for 4 weeks to build a sustained level.

Occasionally there are protocols (for instance, for sciatica) that initially require daily B12 initially.

B12 is frequently combined with B1.

We usually give a full spread of B-Vitamins, as they "back each other up" in numerous biochemical pathways.

Homocysteine and Methylmalonic acid tend to start to rise when the B12 level is below 400pmol/L, so our Naturopathic doctors usually aim for the B12 to be well above 500 pmol/L.

Using MCV is not a reliable marker because it does not always rise, even in major deficiency.

In patients taking acid suppressive medications, or metformin our Naturopaths strongly consider the possibility that the B12 level is suboptimal.

Adverse effects related to B12 are extremely rare with acne eruptions being the most frequent issue that arises.

Occasionally, patients may experience red urine.

B12 is well tolerated with little to no sensation during or after.

There is the concern that higher B12 levels are seen in malignancies but it's thought actually that malignancies may cause an elevated B₁₂ as a reactive feature (like an acute phase protein) vs. high B12 levels causing malignancy.

NADH+ Therapy

We offer Edmonton NADH for fatigue & neurodegenerative issues

NADH Therapy in Edmonton

NADH Facts

Nicotinamide adenine dinucleotide (NADH) is an important Vitamin B3 derived cofactor.

NADH Biochemistry: NADH serves as a key energy-transfer intermediate in the electron transport chain. NADH is the reduced form of nicotinamide adenine dinucleotide NAD+.

Dietary uptake of NAD+ precursors, such as nicotinic acid (Niacin), nicotinamide (Niacinamide) and nicotinamide riboside (NR), which in mammals are converted into NAD+ through the salvage pathway and the kynurenine pathway converts Tryptophan to generate NAD+.

Nicotinamide and Nicotinamide Riboside (NR) become nicotinamide mononucleotide (NMN) which then converts to NAD+ which suggests that oral intake of NMN is preferable to all other NAD+ precursors.

NAD+ as NADPH is involved in converting oxidized Glutathione (GSSG) back to reduced Glutathione (via Glutathione reductase).

NAD+ treatments can be combined with Vitamins for an additive effect as they support each other in the main biochemical pathways.

Although NADH is the end product of NAD+, we have seen much more robust results with NAD+ over NADH.

Our Naturopaths consider NADH Therapy with conditions known to have mitochondrial dysfunction such as neurodegenerative conditions such as Parkinson's and chronic fatigue.

Most of the data on NADH comes from studies in the 90s in Parkinson's disease and has been studied in Chronic fatigue syndrome.

NADH Studies:

NADH might reduce symptoms of CFS when used alone, in combination with coenzyme Q10.

In one study, patients with CFS taking NADH 5-10 mg daily for 24 months experienced a 42% reduction in symptoms compared to baseline in the first 3 months.

885 Parkinson's patients were given 12.5mg of NADH with a positive clinical effect in 80%, with about 20% of those showing a substantial improvement (up to 50% improvement) and 60% of those, showing moderate improvement.

NADH is thought to stimulate endogenous L-DOPA (might increase tyrosine hydroxylase activity).

NADH was given every other day for 14 days. The intravenous protocol of 12.5mg daily for 7 days has also been used.

NADH Dosing:

Often times our Naturopathic doctors use 10-20mg of NADH given over about 30 minutes.

NADH is generally well tolerated versus NAD+ which can give profound nausea intravenously.

With dosing for therapeutic effect however it appears NADH does require more frequent dosing for it to have a clinical effect.

We often give Glutathione after NADH especially for Parkinson's at our Edmonton office.

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