Other Treatments our Naturopaths work with:
Curcumin Alpha Lipoic Acid PolyMVA NADH B12 Curcumin in EdmontonOur Naturopaths work with Curcumin Treatment
Curcumin "diferuloylmethane" is a yellow pigmented active ingredient from Turmeric (Curcuma longa) Curcumin Facts Curcumin basics:Curcumin has numerous effects on cancer cell including inhibition of NF-κB, and affects common cancer pathways utilizing STAT3, mTOR and transforming growth factor (TGF)-β as well as affecting apoptosis. Curcumin is notoriously poorly absorbed and various efforts have gone into attempting to increase the availability of Curcumin. Our Naturopaths typically ramp the dose and usually give doses between 300 to 500 mg of per session. Curcumin is well tolerated when diluted appropriately. Curcumin treatment can be given back to back with Quercetin for synergistic effects in Cancer and inflammation.
Curcumin and CancerPreliminary data: Cell line evidence exists in breast, prostate, lung, bladder, cervical and gastric cancer (in combination with quercetin in particular which we can also give intravenously), melanoma, multiple myeloma, glioblastoma, and chronic myelogenous leukemia. Colon Cancer - Oral curcumin in advanced colorectal cancer patients refractory to standard chemotherapies resulted in stable disease for 2-4 months in five of fifteen patients. Pancreatic Cancer - As a standalone treatment, high dose Curcumin caused ongoing stable disease for one patient and tumor regression in another in a 2008 trial. In combination with Gemcitabine it increased median survival time in a 2011 and 2010 study.
Prostate Cancer - In a 2019 trial, patients who finished the period of androgen deprivation were given curcumin or placebo group and the proportion of patients with PSA progression was significantly lower in the Curcumin group. Curcumin Phase I Study using liposomal curcumin showed marked reductions in tumor markers in one colorectal cancer patient as well as a prostate cancer patient. Doses given were 200-500mg which is similar to the strength we use at our Edmonton office for a single treatment. Beyond CancerPain: Curcumin can improve symptoms of Osteoarthritis. Cardiovascular Disease: Oral curcuminoids can reduce triglycerides, increase HDL and reduce LDL. Mood: Oral curcumin can improves symptoms of depression when taken along with an antidepressant. Autoimmunity: Data exists demonstrating beneficial effects of Curcumin in Ulcerative Colitis, Crohn's & Psoriasis. Bottom line: Curcumin is notoriously poorly absorbed when taken by mouth Our Naturopathic Doctors use Curcumin in Cancer, Pain and Autoimmunity |
ALAAnti-oxidant, Anti-inflammatory & Glutathione Boosting
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B12 Treatment
A master for energy, mood, focus and memory.B12 in EdmontonB12 FactsVitamin B12 has two active forms, methylcobalamin and adenosylcobalamin "cobamamide"
B12 Biochemistry:Adenosylcobalamin is the major form in cells that's stored in the mitochondria whereas Methylcobalamin is found in the cytosol of the cell and it predominates in blood.
Insanely, humans require B12 for just two enzymes: methylmalonyl-CoA mutase & methionine synthase.
Adenosylcobalamin is a cofactor for the enzyme methylmalonyl-CoA mutase that catalyzes the conversion of methylmalonyl-CoA to succinyl-CoA, which is a key component of the Krebs Cycle for energy production.
So it's quite possible that administration of the Adenosyl form of B12 may in fact be superior to other forms for fatigue.
Our Naturopaths measure methylmalonic acid as part of our DUTCH hormone test - so, if your Adenosylcobalamin is low, then the methylmalonyl-CoA builds up and we can measure it in the urine. THIS IS IN THE MITOCHONDRIA.
Methylcobalamin methylates homocysteine to methionine (via methionine synthase). The cobalamin is then remethylated from methyltetrahydrofolate, which results in the formation of tetrahydrofolate. This is in the CYTOPLASM.
In the blood, Transcobalamin-B12 complex is taken up into cells by receptor-mediated endocytosis after binding to the transcobalamin receptor.
Then methyl and adenosyl are cleaved back into a cobalamin, by binding to the CblC protein which requires Glutathione to work.
If the cobalamin reacts with water it forms Hydroxocobalamin.
Reductive methylation of cobalamin to methylcobalamin is done using methionine synthase reductase in which SAMe acts as a methyl donor
Once cobalamin enters the mitochondria, it's adenosylated to make adenosylcobalamin.
B12 Uses:B12 is a mainstay at our Edmonton office for fatigue, especially if there are simultaneous neuropsychiatric concerns like anxiety or depression.
B12 is a marvelous treatment that works extremely rapidly.
The RDA for B12 is around 2.5 μg/day, which is also the amount that saturates intrinsic factor, and then there is some passive diffusion of B12 which happens in the digestive tract as well. This RDA, is the lowest of all the vitamins but with that said, it is probably the one that benefits the most from doses that dramatically exceed this, especially when given via different routes.
Our Naturopaths use B12 for improving a wide variety of health areas including:
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Cardiovascular |
Hyperhomocysteinemia |
Dermatological |
Herpes zoster |
Urticaria |
Ear, nose, and throat |
Hearing loss |
Olfactory dysfunction (if deficient) |
Taste disorders (if deficient) |
Tinnitus |
Musculoskeletal |
Low Back pain |
Bursitis |
Heel Spurs |
Neurological |
Migraine |
Neuritis |
Peripheral neuropathy |
Sciatica |
Trigeminal neuralgia |
Autism |
Psychiatric |
Alzheimer’s disease |
Anxiety |
Dementia/cognitive decline |
Depression |
Postpartum depression |
Other |
Age-related macular degeneration |
Alcohol addiction |
Anesthesia side effects |
Aphthous ulcers |
Asthma |
Chronic fatigue syndrome |
Diabetes |
Fatigue |
B12 Dosing:Our Naturopathic Doctors are usually dosing between 1.5mg to 15mg depending on the concerns and frequently use Methylcobalamin, but have used Hydroxocobalamin and are gaining experience with Adenosylcobalamin.
The B12 dose will be individualized by your Naturopath depending on your specific concern.
For most health conditions, it's given 1x weekly for 4 weeks to build a sustained level.
Occasionally there are protocols (for instance, for sciatica) that initially require daily B12 initially.
B12 is frequently combined with B1.
We usually give a full spread of B-Vitamins, as they "back each other up" in numerous biochemical pathways.
Homocysteine and Methylmalonic acid tend to start to rise when the B12 level is below 400pmol/L, so our Naturopathic doctors usually aim for the B12 to be well above 500 pmol/L.
Using MCV is not a reliable marker because it does not always rise, even in major deficiency.
In patients taking acid suppressive medications, or metformin our Naturopaths strongly consider the possibility that the B12 level is suboptimal.
Adverse effects related to B12 are extremely rare with acne eruptions being the most frequent issue that arises.
Occasionally, patients may experience red urine.
B12 is well tolerated with little to no sensation during or after.
There is the concern that higher B12 levels are seen in malignancies but it's thought actually that malignancies may cause an elevated B12 as a reactive feature (like an acute phase protein) vs. high B12 levels causing malignancy.
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NADH+ TherapyWe offer Edmonton NADH for fatigue & neurodegenerative issues
NADH Therapy in EdmontonNADH FactsNicotinamide adenine dinucleotide (NADH) is an important Vitamin B3 derived cofactor. NADH Biochemistry: NADH serves as a key energy-transfer intermediate in the electron transport chain. NADH is the reduced form of nicotinamide adenine dinucleotide NAD+. Dietary uptake of NAD+ precursors, such as nicotinic acid (Niacin), nicotinamide (Niacinamide) and nicotinamide riboside (NR), which in mammals are converted into NAD+ through the salvage pathway and the kynurenine pathway converts Tryptophan to generate NAD+. Nicotinamide and Nicotinamide Riboside (NR) become nicotinamide mononucleotide (NMN) which then converts to NAD+ which suggests that oral intake of NMN is preferable to all other NAD+ precursors. NAD+ as NADPH is involved in converting oxidized Glutathione (GSSG) back to reduced Glutathione (via Glutathione reductase). NAD+ treatments can be combined with Vitamins for an additive effect as they support each other in the main biochemical pathways. Although NADH is the end product of NAD+, we have seen much more robust results with NAD+ over NADH. Our Naturopaths consider NADH Therapy with conditions known to have mitochondrial dysfunction such as neurodegenerative conditions such as Parkinson's and chronic fatigue. Most of the data on NADH comes from studies in the 90s in Parkinson's disease and has been studied in Chronic fatigue syndrome. NADH Studies:NADH might reduce symptoms of CFS when used alone, in combination with coenzyme Q10. In one study, patients with CFS taking NADH 5-10 mg daily for 24 months experienced a 42% reduction in symptoms compared to baseline in the first 3 months. 885 Parkinson's patients were given 12.5mg of NADH with a positive clinical effect in 80%, with about 20% of those showing a substantial improvement (up to 50% improvement) and 60% of those, showing moderate improvement. NADH is thought to stimulate endogenous L-DOPA (might increase tyrosine hydroxylase activity). NADH was given every other day for 14 days. The intravenous protocol of 12.5mg daily for 7 days has also been used. NADH Dosing:Often times our Naturopathic doctors use 10-20mg of NADH given over about 30 minutes. NADH is generally well tolerated versus NAD+ which can give profound nausea intravenously. With dosing for therapeutic effect however it appears NADH does require more frequent dosing for it to have a clinical effect. We often give Glutathione after NADH especially for Parkinson's at our Edmonton office. Need Help? |
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